Endocrine Abstracts

Background: Type 1 diabetes mellitus is frequently associated with endocrine autoimmune diseases especially thyroid disorders. These could have a negative impact on glycemic control even if there is no clinical evidence of thyroid dysfunction.The aim of the study was to evaluate thyroid function in a group of children with type 1 diabetes mellitus (T1DM) and no clinical evidence of thyroid diseases and to determine its impact on glycemic control.<p c...

Aim of this study was to evaluate the effectiveness and safety of oral anticoagulant therapy in patients with atrial fibrillation and hyperthyroidism compared to those presenting the same cardiac disorder, but with normal thyroid function.Material and methods: The study included 61 patients admitted to the Endocrinology Department in Elias Hospital between January 2011–October 2011 with mean age of 64 years: 25 patients had primary hyperthyroidism a...

Introduction: The risk for the development of germ cell tumors is hard to predict in patients with disorders of sex development (DSD) and their optimal management has been a continuous matter of debate. The risk varies between unknown and 40–60% in Denys-Drash/Frasier syndrome. This malignant potential opposes itself firmly to the recent interest in a more conservative approach regarding gonadectomy.Case presentation: We present the case of a 20-yea...

Introduction: Autoimmune thyroid disease affects 1% of the population and comprises several disorders, including Graves’ disease(GD). Local and serum cytokines are increased in patients with Graves disease, play a central role in co-ordinating immune reactions and have immunolgical and functional effects on thyroid cells.Aim: To investigate serum inflammatory and cytokines profile in untreated patients with Graves’ disease at diagnosis, when th...

Introduction: Aggressive angiomyxoma is a rare, benigne, misdiagnosed tumor that occurs preferentially in women during the reproductive age.Case report: We present a 43-year-old Caucasin woman diagnosed with aggressive multifocal angomyxoma developing for the last 8 years. The patient underwent five surgical procedures during this period of time in order to debulk the pelvis and subperitoneal space of a large invasive tumor. The last surgical approach re...

A large body of evidence suggests that in polycystic ovary syndrome (PCOS) there is a link between abdominal adiposity, visceral adiposity dysfunction and hyperandrogenism and this relationship could be bidirectional. However a well designed study of adipose tissue distribution reported no significant differences between PCOS and controls. Visceral adiposity index (VAI) is a recently reported marker of the cardiovascular risk, strongly correlated with visceral adipose tissue (...

The aim of the study was to evaluate the effects of hyperthyroidia on glycemic control in patients with diabetes mellitus.Research design and methods: We retrospectively evaluated the patients with diabetes and hyperthyroidism. We analysed clinical data, thyroid ultrasound exploration, laboratory analyses (glycosylated hemoglobin, free thyroxin FT4, triiodothyronine T3, thyroid stimulating hormone TSH).Results: We evaluated 48 pati...

Aim: Following the general concern regarding the association between various diabetes treatments and cancer risk, the present study evaluated the cancer specific mortality in adult insulin-treated diabetes patients.Materials and methods: All diabetes patients residing in a major urban area, aged over 40 years and receiving insulin treatment were included at the moment of their first diabetes outpatient visit from 01/01/2001 to 12/31/2008. A total of 1136...

Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting 5–10% of reproductive -age female population.The aim of this study was to determine the clinical features, metabolic and hormonal profile in obese and overweight women with PCOS.Patients and method: A total of 102 women (age 31.28±6.05 and BMI 33.02±5.93) with PCOS and 110 (age 32.35±4.96 and BMI 33.05±5.87) matched controls were invest...

Introduction: The polycystic ovary syndrome (PCOS) and obesity are related, yet different complex diseases, with the same genes possibly playing different roles in each disease. INSIG2, an obesity-associated gene (by rs7566605 C/C genotype) is a good candidate for PCOS. Its genotypes were not associated with obesity in PCOS patients. To date, there are no published association studies of rs7566605 with PCOS itself.Aim: To perform a case-control associati...